Water-drinking test in central serous chorioretinopathy
Abhilash Goud1, Niroj Kumar Sahoo1, Mohammed Abdul Rasheed1, Sumit Randhir Singh1, Samatha Ankireddy2, Kiran Kumar Vupparaboina3, Marco Lupidi4, Jay Chhablani5
1 Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, Telangana, India 2 Department of Ophthalmology, Kansas City School of Medicine, University of Missouri, Kansas City, MO, USA 3 Srujana Centre for Innovation, L.V. Prasad Eye Institute, Hyderabad, Telangana, India 4 Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy 5 Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, Telangana, India; UPMC Eye Centre, University of Pittsburgh, Pittsburgh, PA, USA
Correspondence Address:
Jay Chhablani Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad - 500 034, Telangana
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JOCO.JOCO_225_20
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Purpose: To evaluate choroidal changes in central serous chorioretinopathy (CSCR) patients after water-drinking test (WDT).
Methods: This prospective study included treatment-naïve acute and chronic CSCR eyes and healthy controls. Intraocular pressure and optical coherence tomography measurements with choroidal vascular index (CVI) measurements were done at baseline. Patients were asked to drink 1 L of water, and tests were repeated at 15, 30, and 45 min.
Results: Fifty-six eyes from 42 patients were enrolled. Choroidal area, luminal area, and stromal area were higher at baseline in eyes with acute CSCR compared to healthy controls. Chronic CSCR eyes showed an increase in choroidal area and stromal area and a decrease in the luminal area at 15 min. There was a significant decrease in CVI at 30 and 45 min in chronic CSCR and CVI at 45 min in fellow eyes of acute CSCR. Repeated-measures analysis of variance (ANOVA) showed a significant change in central macular thickness in acute CSCR, choroidal thickness in fellow eyes of acute CSCR, stromal area, and total choroidal area in chronic CSCR. Mixed model ANOVA showed that the change in various choroidal parameters seen had no interaction with the eye type.
Conclusion: Although change in various parameters was seen in acute CSCR, chronic CSCR, and fellow eyes of acute CSCR following WDT, the change was not significantly different among the groups.
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